Skull of a Skeleton with Burning Cigarette is an early work by Vincent van Gogh. The small and undated oil-on-canvas painting featuring a skeleton and cigarette is part of the permanent collection of the Van Gogh Museum in Amsterdam.

The piece was created using oil paint on canvas, a common medium for easel painting at the time. The small painting measures 32 cm × 24.5 cm (approximately 13 in × 9.6 in).